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Neurosci Lett. 1981 Jun 12;24(1):53-7.

Proconvulsant effects in baboons of beta-carboline, a putative endogenous ligand for benzodiazepine receptors.


beta-Carboline-3-carboxylic acid ethyl ester (beta-CCE) was tested on two models of epilepsy in the baboon: kainic acid-induced limbic status epilepticus and photosensitive epilepsy. Beta-CCE, at very low doses ranging from 8 to 100 microgram/kg (i.v.), induced a reactivation of the limbic focus and photomyoclonic and generalized seizures in photosensitive and non-photosensitive baboons. The proconvulsant effect of beta-CCE may be associated with its binding to a particular subclass of benzodiazepine receptors.

[Indexed for MEDLINE]

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