Send to

Choose Destination
Nature. 1981 Jun 18;291(5816):547-53.

Primary structure, gene organization and polypeptide expression of poliovirus RNA.


The primary structure of the poliovirus genome has been determined. The RNA molecule is 7,433 nucleotides long, polyadenylated at the 3' terminus, and covalently linked to a small protein (VPg) at the 5' terminus. An open reading frame of 2,207 consecutive triplets spans over 89% of the nucleotide sequence and codes for the viral polyprotein NCVPOO. Twelve viral polypeptides have been mapped by amino acid sequence analysis and were found to be proteolytic cleavage products of the polyprotein, cleavages occurring predominantly at Gln-Gly pairs.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center