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Immunogenetics. 1980 Jul;11(1):87-92.

Resistance to HSV-1 in the mouse is governed by two major, independently segregating, non-H-2 loci.

Abstract

Earlier studies showed that genetic resistance of adult, inbred strains of mice to Herpes Simplex Virus-type 1 (HSV-1) is a dominant genetic trait. The present studies were undertaken to determine the number of genetic loci involved and whether they were found within the major histocompatibility complex, H-2, of the mouse. Challenge with HSV-1 of progeny of mice backcrossed to moderately susceptible BALB/c mice, of progeny of mice backcrossed to very susceptible A/J strain mice, and of progeny of the F-2 cross using (C57BL/6 x A/J)F1 mice indicated that two major loci were responsible for resistance. The backcrosses to BALB/c mice suggested that additional genes on this background enhanced resistance, while further backcrosses with the A/J mice indicated that other genes on the A/J background (or the lack thereof) reduced resistance. Studies with congenic mice showed that genes within the H-2 did not influence resistance or susceptibility.

PMID:
6254873
DOI:
10.1007/bf01567772
[Indexed for MEDLINE]

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