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Nucleic Acids Res. 1980 Apr 11;8(7):1499-504.

DNA methylation and the frequency of CpG in animal DNA.

Abstract

An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes.

PMID:
6253938
PMCID:
PMC324012
[Indexed for MEDLINE]
Free PMC Article

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