Immunoglobulin A antibody to Epstein-Barr viral antigens and prognosis in nasopharyngeal carcinoma

Otolaryngol Head Neck Surg (1979). 1980 Jan-Feb;88(1):52-7. doi: 10.1177/019459988008800115.

Abstract

IgA immunoglobulin fractions containing antibodies to Epstein-Barr virus (EBV)-induced membrane antigens were isolated from the sera of two patients with nasopharyngeal carcinoma (NPC), from one non-NPC patient, and from three persons with sera negative for IgA antibodies. IgA antibodies were not cytotoxic against cells expressing EBV-induced membrane antigens in the antibody-dependent cellular cytotoxicity (ADCC) assay. However, IgA antibodies blocked IgG-mediated ADCC, which indicated that these antibodies could serve as a blocking "factor" in patients with disease and, therefore, were potentially detrimental to the host.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Viral / immunology*
  • Antigens, Viral / immunology*
  • Binding, Competitive
  • Cytotoxicity Tests, Immunologic
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Immunoglobulin A / analysis
  • Immunoglobulin A / immunology*
  • Immunoglobulin G / analysis
  • Immunoglobulin G / immunology
  • Nasopharyngeal Neoplasms / immunology*
  • Nasopharyngeal Neoplasms / therapy
  • Prognosis

Substances

  • Antibodies, Viral
  • Antigens, Viral
  • Immunoglobulin A
  • Immunoglobulin G