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Biochem J. 1980 Mar 1;185(3):775-7.

Novel inhibitors of poly(ADP-ribose) synthetase.

Abstract

In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. Two of the benzamides, 3-aminobenzamide and 3-methoxybenzamide, were found to be competitive inhibitors, with Ki values or less than 2 microM.

PMID:
6248035
PMCID:
PMC1161458
DOI:
10.1042/bj1850775
[Indexed for MEDLINE]
Free PMC Article

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