Mitochondrial water in myocardial ischemia: investigation with nuclear magnetic resonance

Science. 1980 Jun 13;208(4449):1267-9. doi: 10.1126/science.6246584.

Abstract

Nuclear magnetic resonance studies of mitochondria isolated from ischemic hearts after coronary vessel occlusion indicated a decrease in water proton relaxation times. This change coincided with a decrease in the hydration of the samples. It is suggested that in ischemia, changes in macromolecular hydration may be one of the first mechanisms to alter function in the mitochondria, which are vital to the energy-transducing process in heart muscle.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Fractionation / methods
  • Coronary Disease / metabolism*
  • Coronary Disease / pathology
  • Dogs
  • Magnetic Resonance Spectroscopy
  • Mitochondria, Heart / metabolism*
  • Protons
  • Water / metabolism*

Substances

  • Protons
  • Water