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Eur J Pharmacol. 1980 Feb 8;61(3):313-5.

Tonic analgesic effects of delta 9-tetrahydrocannabinol as measured with the formalin test.


The analgesic effects of delta 9-tetrahydrocannabinol (THC), the psychoactive component of marihuana, were tested using the formalin test. Rats were treated with either THC (5 mg/kg or 10 mg/kg) or a placebo by gavage 4 h before the formalin test for analgesia was initiated. THC produced a highly significant analgesic effect against both phasic pain and tonic pain. THC is discussed as a model for the development of new analgesics or as a suitable analgesic if used with another potentiating drug.

[Indexed for MEDLINE]

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