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Nature. 1980 Feb 28;283(5750):826-31.

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine.

Abstract

The Abelson murine leukaemia virus protein (P120) can become phosphorylated in vitro by [gamma-32P]ATP. The protein has been purified from cell membranes to the point that in specific conditions virtually all of the incorporated 32P is in P120. The reaction is stimulated by Mn2+ and Mg2+ but not Ca2+ and is very rapid even at 0 degrees C. The phosphate is linked to P120 at tyrosine, a linkage not previously reported for a phosphorylation reaction. Phosphorylation may be involved in the transforming activity of viruses that cause leukaemia as well as sarcomas.

PMID:
6244493
DOI:
10.1038/283826a0
[Indexed for MEDLINE]

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