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FEBS Lett. 1984 Jul 23;173(1):134-8.

Echinocandin inhibition of 1,3-beta-D-glucan synthase from Candida albicans.

Abstract

The cyclic peptide antibiotic echinocandin was found to inhibit 1,3-beta-D-glucan synthase activity present in a mixed membrane fraction from Candida albicans. Addition of antibiotic reduced the Vmax of the enzyme, but the Km was unaffected. GTP stimulated enzyme activity approximately 4-fold, but did not affect the percentage inhibition of the enzyme by echinocandin. Treatment of the reaction products with alpha-amylase and beta-glucanase confirmed that the polymer synthesised was 1,3-beta-D-glucan, not glycogen.

PMID:
6235127
DOI:
10.1016/0014-5793(84)81032-7
[Indexed for MEDLINE]
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