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Contraception. 1984 Mar;29(3):261-70.

Changes in serum apo-lipoprotein AI and sex-hormone-binding globulin levels after treatment with two different progestins administered alone and in combination with ethinyl estradiol.

Abstract

Twenty women, oophorectomized as part of the surgical treatment for cervical carcinoma in either clinical stage IB or IIA but otherwise healthy, participated in the study. After a period of six weeks without hormonal treatment, ten of them were given 150 micrograms desogestrel (DG) daily for three weeks followed by 150 micrograms DG + 30 micrograms ethinyl estradiol (EE) for six weeks and, finally, 30 micrograms EE alone for three weeks. The remaining ten women were given 150 micrograms levonorgestrel (NORG) and EE in a similar regimen. Before treatment and after each period of treatment, apo-lipoprotein AI and sex-hormone-binding globulin (SHBG) were assayed in serum. Both progestins decreased apo-AI and SHBG when given alone, thereby indicating an "androgenic" influence. In combination with EE, however, DG seems to be less "anti-oestrogenic" than NORG, as judged from the higher apo-AI and SHBG values after the combination DG + EE compared to those after NORG + EE.

PIP:

20 women, oophorectomized as part of the surgical treatment for cervical carcinoma in either clinical stage IB or ITA but otherwise healthy, paticipated in the study. After a 6-week period without hormonal treatment, 10 of them were given 150 mcg desogestrel (DG) daily for 3 weeks followed by 150 mcg DG & 30 mcg ethinyl estradiol (EE) for 6 weeks and, finally, 30 mcg EE alone for 3 weeks. The remaining 10 women were given 150 mcg levonorgestrel (NORG) and EE in a similar regimen. Before treatment and after each treatment period, apo-lipoprotein AI and sex hormone binding globulin (SHBG) were assayed in serum. Both progestins decreased apo-AI and SHBG when given alone, thereby indicating an androgenic influence. In combination with EE, however, DG seems to be less antiestrogenic than NORG, as judged from the higher apo-AI and SHBG values after the combination of DG EE compared to those after NORG & EE.

PMID:
6234148
DOI:
10.1016/s0010-7824(84)80006-2
[Indexed for MEDLINE]

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