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Biochem Biophys Res Commun. 1983 Jul 18;114(1):93-8.

Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity.

Abstract

Proliferation of lectin-treated mouse thymocytes induced by the tumor promoter, 12-0-tetradecanoyl-13-acetate, is markedly inhibited by cAMP analogues, prostaglandin E and methylisobutylxanthine. Proliferation induced by interleukin-2 is resistant to inhibition by these compounds. The tumor promoter induces interleukin-2 production in a subpopulation of lectin-treated thymocytes, and production of this lymphokine is inhibited by agents that increase cellular cAMP.

PMID:
6192817
DOI:
10.1016/0006-291x(83)91598-x
[Indexed for MEDLINE]

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