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Antimicrob Agents Chemother. 1982 Nov;22(5):824-31.

7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase.

Abstract

Aminoglycoside-2"-O-adenylyltransferase was inhibited by 7-hydroxytropolone. Inhibition was competitive with respect to the cosubstrate ATP and appeared to require the unique vicinal arrangement of oxygens found in 7-hydroxytropolone. Combinations of 7-hydroxytropolone plus the appropriate aminoglycoside substrates were active against resistant bacteria possessing the adenylyltransferase. No potentiation was observed against other aminoglycoside-resistant or -susceptible strains. The fact that the inhibition of an aminoglycoside-modifying enzyme overcomes the poor uptake of aminoglycosides in resistant strains points to the singular importance of the inactivating enzyme as a determinant of resistance.

PMID:
6185088
PMCID:
PMC185667
DOI:
10.1128/aac.22.5.824
[Indexed for MEDLINE]
Free PMC Article

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