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J Cell Physiol Suppl. 1982;1:137-43.

The control of globin and other eukaryotic genes.

Abstract

The hypothesis is advanced that eukaryotes control different parts of their genomes by the selective use of origins of replication. Replication of a gene from an origin upstream of the gene is postulated to open it for transcription under appropriate circumstances; replication of a gene from an origin downstream of the gene closes it. The applicability of this hypothesis to the control of the human beta-globin cluster of genes is considered.

PMID:
6175650
[Indexed for MEDLINE]

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