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Eur J Pharmacol. 1982 Mar 12;78(3):357-61.

Effect of salbutamol on the cerebral levels, uptake and turnover of serotonin.

Abstract

The effect of salbutamol (SB) on the cerebral levels of serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) was determined as well as the effect on the uptake and turnover of 5-HT in rat brain. SB failed to inhibit the cerebral uptake of 5-HT and did not change 5-HT and 5-HIAA levels in the brain; however, it significantly increased the cerebral turnover of 5-HT. The latter effect may partly be responsible for the antidepressant properties of the compounds.

PMID:
6175524
DOI:
10.1016/0014-2999(82)90038-3
[Indexed for MEDLINE]

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