Send to

Choose Destination
See comment in PubMed Commons below
Am J Pathol. 1982 Mar;106(3):388-93.

Age-associated C-cell hyperplasia in the human thyroid.


C cells in 26 normal human thyroids from forensic autopsies were identified by immunoperoxidase staining for calcitonin. C-cell concentrations and total C-cell numbers were determined with the use of morphometric techniques. There was great variation in C-cell density within a given gland and among individuals, although C cells tended to concentrate about one third of the way down the vertical axis of the lateral lobes. Densities of 1-2000 cells/cu mm were found in the third and later decades. In addition there was a statistically significant (P less than 0.01) positive Spearman correlation between total C-cell numbers and age in males. C-cell hyperplasia appears to be an age-related phenomenon that may have physiologic significance and must be taken into consideration in evaluation of thyroid glands for the diagnosis of premalignant lesions of C cells.

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons


    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center