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Clin Nephrol. 1981 Mar;15(3):148-53.

Recurrent hemolytic uremic syndrome during oral contraception.


A 23-year-old multiparous normotensive woman developed a hemolytic uremic syndrome (HUS) five months postpartum, and four months after starting estro-progestogen contraception. Eight years later a recurrence appeared, five years after a successful cadaver kidney transplantation and ten months after resumption of the estro-progestogen intake. In the interval a pure progestogen contraceptive was prescribed without problems. This observation is consistent with the hypothesis that HUS can be triggered by oral estrogen intake in predisposed individuals.


A case is reported of a 23-year-old multiparous normotensive woman who developed HUS (hemolytic uremic syndrome) on 2 occasions. Both episodes had been preceded by relatively short periods of estrogen-progestogen contraceptive usage. Neither episode was accompanied by arterial hypertension. This syndrome is characterized by acute renal failure associated with histological lesions of thrombotic microangiopathy. Laboratory findings, treatment, and kidney transplant in both of the episodes are described. The 1st instance occurred 5 months postpartum and 4 months after starting the OC (oral contraceptive) use. The 2nd instance occurred 10 months after starting OC usage. In the intervening 8 years, the patient had used a pure progestogen contraceptive without problems. A table presents findings from a review of the literature regarding an association between HUS and estrogen use.

[Indexed for MEDLINE]

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