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Nature. 1980 Dec 11;288(5791):551-6.

Angiogenesis in vitro.

Abstract

Cloned capillary endothelial cells, cultured in tumour-conditioned medium, form capillary tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first demonstration of angiogenesis in vitro: (1) shows that all the information necessary to develop an entire capillary network in vitro is expressed by one cell type; (2) suggests a mechanism for lumen formation; and (3) offers a possibility of distinguishing between direct and indirect angiogenesis factors.

PMID:
6160403
DOI:
10.1038/288551a0
[Indexed for MEDLINE]

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