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J Gen Microbiol. 1984 May;130(5):1089-95.

The role of common and type-specific pilus antigenic domains in adhesion and virulence of gonococci for human epithelial cells.

Abstract

A panel of monoclonal antibodies with varying pilus specificities ranging from cross-reacting to type-specific has been used to investigate the role of conserved and variable antigenic domains in the adhesion of gonococci to human epithelial cells. The binding of 125I-labelled alpha pili from strain P9 to buccal epithelial cells was inhibited by three type-specific but not by two cross-reacting antibodies. Four type-specific antibodies inhibited the binding of gamma pili while the two cross-reacting antibodies were again without effect. The virulence of the variants P9-2 (alpha pili) and P9-35 (gamma pili) for Chang conjunctiva epithelial cells was similarly reduced only in the presence of relevant type-specific antibodies. These results indicate the importance of variable antigenic domains in the adhesion of gonococci to human epithelial cells.

PMID:
6147388
DOI:
10.1099/00221287-130-5-1089
[Indexed for MEDLINE]

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