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Lancet. 1984 May 5;1(8384):989-90.

Recombinant leucocyte interferon A induces steroid-resistant acute vascular rejection episodes in renal transplant recipients.


In an attempt to determine the safety, tolerance, and prophylactic antiviral activity of high doses of recombinant DNA leucocyte interferon A a double-blind parallel-group study was started in 16 renal transplant recipients. All 16 patients had early rejection episodes. In all 8 interferon-treated patients and 1 placebo-treated patient this rejection, which was of the acute vascular humoral type, was steroid resistant. 3 interferon-treated patients also had transient nephrotic syndrome.

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