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Lancet. 1983 Dec 10;2(8363):1337-8.

Topical cholesterol treatment of recessive X-linked ichthyosis.

Abstract

In an open prospective half-side trial, creams containing 10% cholesterol or 10% urea were applied to lesions in 20 steroid-sulphatase-deficient male patients with recessive X-linked ichthyosis. In 18 there was a good response to the cholesterol cream. In 13 patients the response to cholesterol was better than that to urea. None showed a better response to urea than to cholesterol. A reduction in the cholesterol content of the stratum corneum may be responsible for abnormal cornification in recessive X-linked ichthyosis.

PMID:
6139672
DOI:
10.1016/s0140-6736(83)91093-0
[Indexed for MEDLINE]

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