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Lancet. 1983 Aug 20;2(8347):424-6.

Reversal of hepatic alpha-1-antitrypsin deposition after portacaval shunt.

Abstract

End-to-side portacaval shunts were carried out in three children with the liver disease of alpha-1-antitrypsin deficiency and complications of portal hypertension. Their clinical courses have been stable for 3 1/2 to almost 7 years. Postoperative liver biopsy material from two of the patients showed the typical histopathological changes caused by portal diversion, as well as an apparent reduction in the quantity of alpha-1-antitrypsin particles in the hepatocytes. The metabolic changes caused by portal diversion have apparently created a more favourable equilibrium between the synthesis and excretion of the abnormal alpha-1-antitrypsin.

PMID:
6135912
PMCID:
PMC2981405
[Indexed for MEDLINE]
Free PMC Article
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