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Int J Fertil. 1983;28(1):55-6.

Vitamin E (alpha tocopherol) in the management of menorrhagia associated with the use of intrauterine contraceptive devices (IUCD).



The cause of increased menstrual blood loss (MBL) in a certain percentage of women using IUDs is not known. A recent study showed that the endometrium of IUD-menorrhagic women yielded the highest level of hydrogen peroxide and the nonIUD control group yielded the least. Several antioxidants including vitamin E were found to control peroxidation of tissue lipids. 51 patients attending a family planning clinic in the SSKM Hospital in Calcutta, and seeking medical relief from menorrhagia following the insertion of IUDs were studied. On admission 45% were cases of postinsertional traumatic bleeding, 55% of intractable uterine bleeding which developed spontaneously after having the IUD in the uteri for 6-33 months. Each patient was put on vitamin E with an initial dose of 100 mg/day on alternate days for 14 days. If necessary repetition of the treatment was made at the rate of 1 capsule/day; placebos were given to 7 subjects in the same dose schedule and their responses followed for 2 consecutive cycles only. Practically every subject responded positively to vitamin E treatment and the MBL was returned to normal limits. In the group carrying the IUD for 1-12 months only 25.8% were cured by a single course of 7 capsules whereas in 11 cases (35.8%) there was required 14 capsules and the remaining 12 needed 3-5 courses to recover fully. But with the group wearing IUDs for 13-33 months, 4 required 1 course, 9 2 courses, and 7 3-5 courses. The placebo group did not show any change.

[Indexed for MEDLINE]

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