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Pharmacol Biochem Behav. 1983 Feb;18(2):159-62.

Neurotransmitters extraction by local intracerebral dialysis in anesthetized rats.


A new technique for in vivo neurotransmitter extraction was developed. Perfusion U shaped cannulae were chronically implanted in the caudate or the thalamus of rats. A segment of the cannula was a piece of dialysis tube of molecular weight cut off 1000. Measurable amounts of dopamine and norepinephrine were recovered from the perfusion fluid. Intraperitoneal amphetamine 10 mg/kg increased dopamine output from the caudate but not from the thalamus. The potential applications of this technique are discussed.

[Indexed for MEDLINE]

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