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Lancet. 1982 Nov 20;2(8308):1129-31.

Wearable artificial endocrine pancrease with needle-type glucose sensor.


Miniaturisation of the bedside artificial endocrine pancreas in necessary to provide a means of restoring physiological glycaemic excursions in diabetic patients in the long term. One of the remaining problems in producing such a sophisticated device is the difficulty in developing a sufficiently small glucose-monitoring system. A needle-type glucose sensor has been developed which is suitable for use in a closed-loop glycaemic control system. The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs: the device produced perfect control of blood glucose for up to 7 days.

[Indexed for MEDLINE]

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