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Br J Anaesth. 1982 May;54(5):513-6.

Binding of tubocurarine, fazadinium, pancuronium and Org NC 45 to serum proteins in normal man and in patients with cirrhosis.


The protein binding of four non-depolarizing neuromuscular blocking drugs-tubocurarine, fazadinium, pancuronium and Org NC45-was measured, in serum from normal patients and from patients with cirrhosis of the liver, by an ultracentrifugation method. The fraction bound to serum protein in normal patients was 56% for tubocurarine, 51% for fazadinium, 29% for pancuronium and 30% for Org NC 45. In patients with cirrhosis, the protein binding of the four drugs was similar to that obtained in the normal patient.

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