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J Med Chem. 1981 Oct;24(10):1211-4.

beta-Adrenergic blocking agents. alpha- and gamma-methyl(aryloxy)propanolamines.

Abstract

A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for beta 1-antagonist action on guinea pig atria and beta 2-antagonist action on guinea pig tracheal strips. Several gamma-methyl(aryloxy)propanolamines showed affinity for beta receptors and a possible preference for beta 2 receptors.

PMID:
6120233
DOI:
10.1021/jm00142a017
[Indexed for MEDLINE]

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