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Regul Pept. 1981 Nov;2(6):359-69.

Isolation and chemical characterization of somatostatin-28 from rat hypothalamus.

Abstract

A peptide with somatostatin-like immuno- and bioactivity has been isolated from an aqueous extract of 96 800 rat hypothalamic by means of immunoaffinity chromatography, gel filtration and reverse-phase high-performance liquid chromatography (HPLC). Chemical characterization by amino acid analysis, tryptic peptide mapping and retention behavior in two HPLC system showed that the peptide was indistinguishable from somatostatin-28 previously characterized from several species. This evidence suggests that rat hypothalamic somatostatin-28 is identical in structure to porcine and ovine somatostatin-28.

PMID:
6117931
DOI:
10.1016/0167-0115(81)90018-5
[Indexed for MEDLINE]

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