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Lancet. 1981 Sep 26;2(8248):661-4.

Anti-erythrocyte autoimmunisation during chronic falciparum malaria.

Abstract

Anaemia during malaria is not completely understood. Fourteen cases of antierythrocyte autoimmunisation with anti-I specificity were investigated in a Paris hospital during a period of 2 years. The patients lived in Gabon and had not been taking antimalarial chemoprophylaxis. All had chronic malaria (strongly positive antimalarial immunofluorescent antibody tests). All the recognised caused for anti-erythrocyte autoimmunity were excluded. One possible explanation for these observations is some sort of interaction between I antigen and Plasmodium, the result of which facilitated penetration of the erythrocyte by the malarial parasite.

PMID:
6116046
DOI:
10.1016/s0140-6736(81)90998-3
[Indexed for MEDLINE]

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