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Lancet. 1981 Mar 28;1(8222):686-9.

Immunological and pharmacological monitoring in the clinical use of cyclosporin A.

Abstract

Immunological reactivity to donor antigens and serum concentrations of cyclosporin A were monitored in six patients after renal transplantation. At concentrations of 0.1--1.0 microgram/ml cyclosporin A prevented both donor-specific immune reactivity and clinical rejection during the early post-transplant course. Measurement of cyclosporin A levels and immunological indices allowed individual adjustment of the dosage so as to give excellent early graft function with few adverse effects.

PMID:
6110913
DOI:
10.1016/s0140-6736(81)91971-1
[Indexed for MEDLINE]

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