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Cancer Res. 1980 Apr;40(4):998-1001.

Mechanism for exclusion of 5-fluorouracil from DNA.

Abstract

5-Fluorodeoxyuridine 5'-triphosphate is hydrolyzed by the enzyme deoxyuridine triphosphate diphosphohydrolase (EC 3.6.1.23). Uracil-DNA glycosylase removes 5-fluorouracil (FUra) from FUra-containing DNA similar to its removal of uracil from uracil-containing DNA. The absence of FUra in DNA following exposure of cells to FUra can be explained by the activities of these two enzymes.

PMID:
6101994
[Indexed for MEDLINE]
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