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Nature. 1980 Mar 6;284(5751):17-22.

The role of hormone receptors and GTP-regulatory proteins in membrane transduction.

Abstract

Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.

PMID:
6101906
DOI:
10.1038/284017a0
[Indexed for MEDLINE]

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