High-pressure liquid chromatographic assay of ceftizoxime with an anion-exchange extraction technique

Antimicrob Agents Chemother. 1982 Aug;22(2):336-7. doi: 10.1128/AAC.22.2.336.

Abstract

An anion-exchange extraction method was used in conjunction with high-pressure liquid chromatography for assay of ceftizoxime in 181 serum samples. Comparison of this method with bioassay gave a linear regression line described by Y = 1.11 + 0.98 X, with a correlation coefficient of 0.984. The anion-exchange extraction method is a fast, reliable method of preparing serum samples containing ceftizoxime for assay by liquid chromatography.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biological Assay
  • Cefotaxime / analogs & derivatives*
  • Cefotaxime / blood
  • Ceftizoxime
  • Chromatography, High Pressure Liquid / methods*
  • Chromatography, Ion Exchange
  • Humans

Substances

  • Ceftizoxime
  • Cefotaxime