Format

Send to

Choose Destination
Endocr Res. 1984-1985;10(3-4):387-409.

Lipoproteins and the regulation of adrenal steroidogenesis.

Abstract

ACTH has both short-term (acute) and long-term (chronic) effects to regulate steroid hormone biosynthesis in the adrenal cortex. The acute action of ACTH involves the mobilization of cholesterol and its binding to cytochrome P-450scc. The long-term action of ACTH involves the regulation of synthesis of the various enzymes involved in steroidogenesis. Evidence is presented that cholesterol may have a role to play in this regulatory process as it does in the short-term action of ACTH, consistent with the concept that substrates of specific forms of cytochrome P-450 are frequently able to regulate the synthesis of these specific forms.

PMID:
6100249
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center