Format

Send to

Choose Destination
Nature. 1984 Nov 29-Dec 5;312(5993):409-13.

Multiple specific contacts between a mammalian transcription factor and its cognate promoters.

Abstract

The human transcription factor Sp1 binds upstream of certain viral and cellular promoters and activates initiation of RNA synthesis from these promoters by RNA polymerase II. The Sp1 binding sites of both simian virus 40 and a related monkey promoter contain multiple copies of the sequence GGGCGG, three or four of these sequences forming close contacts with Spl. The clustered contacts fall on one strand of the DNA and are arranged similarly in the major groove of the DNA helix in both promoters.

PMID:
6095100
DOI:
10.1038/312409a0
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center