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J Antimicrob Chemother. 1984 Sep;14 Suppl B:117-23.

Cefotaxime in the cerebrospinal fluid and serum in patients with purulent meningitis.

Abstract

Cefotaxime concentrations in the cerebrospinal fluid and serum were determined in patients with purulent meningitis by means of a simple, rapid and reproducible method in agar medium. The CSF concentrations of cefotaxime fluctuated around 4 mg/l. The pharmacokinetics of the antibiotic in relation to the integrity of the blood-brain barrier was studied by means of an assay of the albumin and IgG present in the cerebrospinal fluid and in the serum.

PMID:
6094430
DOI:
10.1093/jac/14.suppl_b.117
[Indexed for MEDLINE]

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