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Int J Psychophysiol. 1984 Jun;1(4):341-3.

beta-Endorphin withdrawal: a possible cause of premenstrual tension syndrome.


The authors propose that premenstrual tension syndrome (PMS) is the result of beta-endorphin withdrawal. Sixteen women were included in this study which measured beta-endorphin levels on the 7th and 24th day of each woman's menstrual cycle. A significant decline in beta-endorphin levels was noted during the progression of the cycle. The severity of symptoms, however, was inversely proportional to the amount of decline in beta-endorphin levels. It is hypothesized that the attenuation of endorphin decline may be a compensatory mechanism to moderate the severity of PMS symptoms.

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