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Nucleic Acids Res. 1984 Sep 11;12(17):6663-71.

Codon usage can affect efficiency of translation of genes in Escherichia coli.

Abstract

By inserting synthetic oligonucleotides into a highly expressed gene in E. coli it has been shown that unfavourable codon usage can reduce the maximum translation rate of a protein. However, in the case of the codon used (AGG), a significant effect on translation was only seen at very high transcription rates from a gene containing multiple copies of the unfavourable codon.

PMID:
6091031
PMCID:
PMC320107
[Indexed for MEDLINE]
Free PMC Article
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