Format

Send to

Choose Destination
Nature. 1984 Sep 6-11;311(5981):33-8.

Sequence requirements for nuclear location of simian virus 40 large-T antigen.

Abstract

A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that was detected in the cytoplasm but not the nucleus of cells. Deletions within the surrounding sequence Lys-128Lys-Lys-Arg-Lys-Val-Glu also produce cytoplasmic large-T and define a region of the protein involved in nuclear location.

PMID:
6088992
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center