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C-polysaccharide in a pneumococcal vaccine.


The 14-valent pneumococcal vaccine, Pneumovax, was found to contain approximately 25o micrograms per ml of the cell-wall antigen, C-polysaccharide (C-Ps), in addition to 100 micrograms per ml of each of the 14 capsular polysaccharides. Rabbit anti-C-Ps antiserum recognized four components of this C-Ps with different antigenic determinants, corresponding to four fragments with different molecular sizes. By lectin affinity chromatography it was demonstrated that some of the C-Ps in the vaccine contained cell-wall residues. The methods used in this study can also be used for the characterization of other polysaccharide preparations.

[Indexed for MEDLINE]

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