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Science. 1967 Jan 13;155(3759):198-200.

Tyrosinase inhibition: its role in suntanning and in albinism.

Abstract

Tyrosinase inhibitor (molecular weight less than 5000; extracted from various melanomas) fully inhibits soluble tyrosinase but only partially inhibits tyrosinase "aggregated" into melanosomes; the inhibitor can be inactivated by ultraviolet light. S91 Albinotyrosinase Type B apparently cannot "aggregate" into melanosomes because its protein carrier is genetically altered. Therefore, albinotyrosinase remains vulnerable to its inhibitor and cannot produce melanin, even though the enzyme has a functioning active center.

PMID:
6015525
[PubMed - indexed for MEDLINE]
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