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Cytogenet Cell Genet. 1977;19(4):197-207.

Gene dose effect: intraband mapping of the LDH A locus using cells from four individuals with different interstitial deletions of 11p.


The quantitative expression of LDH A was studied in hemolysates from four patients with different but overlapping interstitial deletions of the short arm of chromosome 11. Deficiency of LDH A was demonstrated in one patient, and the LDH A locus has been assigned to that segment of 11p for which this patient alone was deficient, i.e., to band 11p12 (region 11p1203 leads to 11p1208).

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