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Science. 1966 Sep 2;153(3740):1127-8.

Diabetes, a new mutation in the mouse.

Abstract

Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man. Abnormal deposition of fat at 3 to 4 weeks of age is followed shortly by hyperglycemia, polyuria, and glycosuria. Accompanying morphological changes in the islets of Langerhans suggest neogenesis to compensate for insulin depletion.

PMID:
5918576
[Indexed for MEDLINE]

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