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Gan. 1976 Feb;67(1):1-10.

Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.


By cloning from cultivation in vitro of a human hepatoblastoma 3 epithelial cell lines were established, all of which produced alpha-fetoprotein and one of which did albumin in culture. Observation with electron microscopy demonstrated desmosomes and glycogen granules in the cytoplasm of these cells. The morphology, growth characteristics, alpha-fetoprotein production, heterotransplantability, and karyology of the cloned cells suggested that these clonal lines were derived from the tumor cells and retained their malignant characteristics.

[Indexed for MEDLINE]

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