Format

Send to

Choose Destination
J Am Chem Soc. 1969 Apr 9;91(8):2177-8.

The structure of the major urinary metabolite of prostaglandin E2 in man.

Abstract

PIP:

This letter reports the structure of the major urinary metabolite formed from prostaglandin E2 (PGE2) in humans. Radiolabeled PGE2 was injected intravenously into male subjects. 50% of the radioactivity was recovered in urine during the first 5 hours and less than 3% during the following 12 hours. The urine was acidified, and this extract was subjected to reversed-phase partition chromatography. Formation of the major metabolite (depicted stereochemically in the text) from PGE2 involved 4 steps of reactions: 1) dehydrogenation of the alcohol group in the side chain; 2) reduction of the trans double bond; 3) 2 steps of beta oxidation; and 4) delta oxidation.

PMID:
5784182
DOI:
10.1021/ja01036a092
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center