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Science. 1968 Jun 28;160(3835):1469-71.

Alcohol preference in the rat: reduction following depletion of brain serotonin.

Abstract

Preference for ethyl alcohol was significantly reduced or totally abolished in rats given orally p-chlorophenylalanine, a tryptophan hydroxylase inhibitor that selectively depletes brain serotonin. Some aversion to alcohol was observed while p-chlorophenylalanine was administered, but the rats' rejection of alcohol was even more marked after the drug was discontinued. Oral administration of alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor that depletes brain catecholamines, slightly reduced selection of alcohol, but preference returned to normal as soon as alpha-methyl-p-tyrosine was terminated.

PMID:
5690148
DOI:
10.1126/science.160.3835.1469
[Indexed for MEDLINE]

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