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J Clin Invest. 1971 Sep;50(9):2000-3.

Progeria: a cell culture study on aging.

Abstract

Progeria is an autosomal recessive disorder showing precocious senility. The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture. Mitotic activity, DNA synthesis, and cloning efficiency are markedly reduced.

PMID:
5564400
PMCID:
PMC292126
DOI:
10.1172/JCI106692
[Indexed for MEDLINE]
Free PMC Article

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