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Nature. 1979 Oct 25;281(5733):650-5.

Design, synthesis and characterisation of a 34-residue polypeptide that interacts with nucleic acids.

Abstract

Based on secondary structure prediction rules and model building a neutral artificial 34-residue polypeptide with potential nucleic acid-binding activity was synthesised. This peptide and its covalent dimer showed strong interaction with cytidine phosphates and single-stranded DNA. The dimer had considerable ribonuclease activity with high preference for cleavage at the 3'-end of C.

PMID:
551285
DOI:
10.1038/281650a0
[Indexed for MEDLINE]

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