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Br Med J. 1970 Nov 28;4(5734):525-7.

Effects of large doses of colistin sulphomethate sodium on renal function.

Abstract

High doses of colistin were used in the treatment of severely ill patients with refractory klebsiella chest and urinary tract infections. At the same time renal function was monitored to determine possible nephrotoxicity. In all patients it produced acute renal failure and in some acute tubular necrosis. Though renal failure contributed to the final cause of death in some cases, in the majority death was due to the primary neurological illness.

PMID:
5483321
PMCID:
PMC1820005
[Indexed for MEDLINE]
Free PMC Article

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