Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians

Science. 1970 Jul 10;169(3941):194-6. doi: 10.1126/science.169.3941.194.

Abstract

A high frequency of Hb J Tongariki (alpha 115 Ala --> Asp) was found in a Kilenge village in New Britain. Heterozygotes had 45 to 50 percent of the Hb J component (determined by cellulose acetate electrophoresis). Two homozygotes for Hb J had no Hb A, suggesting that in this family only one Hbalpha structural locus is present.

MeSH terms

  • Amino Acids / analysis
  • Blood Protein Electrophoresis
  • Chymotrypsin
  • Erythrocytes, Abnormal
  • Genes*
  • Genetics, Population
  • Hemoglobins, Abnormal / analysis*
  • Homozygote*
  • Humans
  • Hydrogen-Ion Concentration
  • Melanesia
  • Pedigree
  • Peptides / analysis*
  • Trypsin

Substances

  • Amino Acids
  • Hemoglobins, Abnormal
  • Peptides
  • Chymotrypsin
  • Trypsin